Skeletal metastases develop in up to 90% of malignancies and frequently cause pathological fractures and severe pain. Multimodal treatment of skeletal metastases is difficult and not causal, in part, because the underlying molecular pathogenesis is poorly understood.

This interdisciplinary consortium combines its specific basic research, translational and clinical expertise with relevant cellular and animal models, state-of-the-art animal and imaging technologies, and validation in humans, to unravel the molecular mechanisms of bone metastases exemplified by breast and prostate cancer and multiple myeloma.

Our specific aims within the second funding period from 2015-2017 are:

(I) to characterize and interfere with the molecular mechanisms of skeletal homing and adhesion of tumor cells such as SDF-1/CXCR4, MCAM, JAMB/C, and Wnt5a (projects 3, 5, and 7)

(II) to unravel the biological relevance of ligands and inhibitors of canonical and non-canonical Wnt signaling in the tumor/bone crosstalk and develop preclinical intervention models (projects 3, 5 and 8)

(III) to develop advanced imaging methods for the above systems on the mesoscopic and microscopic level using multimodal imaging methods and LSFM (projects 7 and 9)

(IV) to characterize the role of T cells and their subpopulations in bone marrow tumor niche conditioning versus tumor cell killing (project 9)

A systemic and concerted analysis of mechanisms of bone metastasis will create detailed knowledge of this complex process and may identify new target molecules for early molecular imaging and novel treatment.

These goals will lead us to the strategic incorporation of novel bone-targeted therapies into oncological treatment concepts. Treating the soil (bone) combined with the seed (primary tumor) is a truly innovative concept that can be paradigmatically tested in the setting of bone metastasis, but may be also representative for a change of paradigm in other sites of tumor manifestation.

Participating institutions:

Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden
  • Medizinische Klinik und Poliklinik III und Zentrum für Innere Medizin

  • Universitätsklinikum Schleswig-Holstein, Christian-Albrechts-Universität zu Kiel
  • Klinik für Diagnostische Radiologie / Molecular Imaging North Competence Center

  • Orthopädische Klinik, Universität Würzburg
  • Orthopädisches Zentrum für Muskuloskelettale Forschung / Orthopedic Center for Musculoskeletal Research
  • Medizinische Klinik und Poliklinik II
  • Technische Universitt Dresden    Christian-Albrechts-Universitt zu Kiel    Julius-Maximilians-Universitt Wrzburg
      © SKELMET. All Rights Reserved.  |   Legal Notice